A Review on Complete Freund’s Adjuvant-Induced Arthritic Rat Model: Factors Leading to its Success

Arthritis-induced adjuvant (AIA) is an established animal model reflecting several clinical manifestations of human arthritis. It provides more understanding pathogenesis and pathways involved in arthritic development for testing various treatment modalities. Complete Freund’s (CFA) one the most known algogenic agents used to develop AIA rodent model. Its wide application increases CFA effects locally systemically following adjuvant-containing mycobacterium exposure in-vivo. This study aims review possible factors producing a successful CFA-induced rat We conducted previous studies determine critical be emphasized. Since arthritis can classified as gout, osteoarthritis, rheumatoid arthritis, among others, that should assessed include different dosage volume, injection site, remission, gender, strain selections successfully